100mg FECO Capsules (30's)
In 2026, 100mg FECO (Full Extract Cannabis Oil) capsules are classified as a "Maximal-Therapeutic" or "End-of-Line" dosage. This level of concentration is roughly 10 times the standard recreational limit and is primarily utilized in palliative care, advanced oncology, and for severe autoimmune crises.
1. Palliative & Oncological Support
At the 100mg threshold, FECO transitions from a symptom-manager to a powerful sedative and metabolic support tool.
Tumor Microenvironment Influence: 2025–2026 laboratory research has focused on high-dose THC/CBD’s ability to induce autophagy (programmed cell death) in certain cancer cells. 100mg doses are often used in "Rick Simpson"-style protocols intended to provide maximum saturations of cannabinoids in the blood.
Chemotherapy Refractory Nausea: For patients where standard anti-emetics (like Ondansetron) fail, 100mg of FECO provides a "neurological block" against nausea by acting on the 5-HT3 receptors in the brainstem.
Wasting Syndrome (Cachexia): 100mg is often the tipping point for reversing severe weight loss in HIV/AIDS or late-stage cancer, providing a persistent, high-level stimulation of the ghrelin ("hunger") hormone.
2. Management of "Refractory" Autoimmunity
For conditions like Lupus, Crohn’s Disease, or severe Rheumatoid Arthritis, 100mg can provide a systemic "reset."
Cytokine Suppression: High-dose FECO significantly suppresses the production of pro-inflammatory cytokines (IL-6 and TNF-alpha). In 2026, this is used to "cool down" an autoimmune flare that has become life-altering.
Intestinal Healing: In Crohn's disease, 100mg doses are used to tighten the intestinal junctions and reduce the "leaky gut" inflammation that drives the disease, often leading to clinical remission in patient-reported outcomes.
Comparison: 100mg vs. Lower FECO Dosages (2026)
| Benefit | 25mg - 50mg (Moderate) | 100mg (Maximal) |
|---|---|---|
| Pain Level | Chronic, nagging pain. | Intractable, bone-deep pain. |
| Functionality | Can often work/socialize. | Functional, but bed rest recommended. |
| Sleep Impact | Helps fall asleep. | Forces deep, heavy sedation. |
| Duration | 6–8 hours. | 8 - 12 hours (due to liver saturation). |
3. The "Heavyweight" Pharmacokinetics
In 2026, taking 100mg in a single capsule changes how your liver processes the oil:
The "First-Pass" Saturation: Because the dose is so high, the liver’s enzymes (CYP3A4) can become temporarily saturated. This means more of the 11-Hydroxy-THC stays in the bloodstream for a longer period.
Lymphatic Transport: 100mg capsules in 2026 are frequently "Nano-Emulsified." This allows the cannabinoids to bypass some of the liver metabolism and enter the lymphatic system directly, leading to a faster onset (45 mins) despite the huge dose.
2026 Safety & "The 100mg Warning"
Due to the extreme potency, 2026 medical boards emphasize three critical safety rules:
Psychological Edge: At 100mg, even experienced users may encounter "The Void"—a period of intense psychoactivity that can lead to panic if the user is not in a safe, controlled environment.
Blood Sugar Monitoring: High doses can cause a rapid drop in blood glucose. Diabetics must monitor their levels closely as a 100mg capsule may cause unexpected hypoglycemia.
Patient Advice: If you are using 100mg capsules, you should not plan to drive or operate machinery for at least 12 hours after the dose.
